Epigenetics and Transcription

Wen Laboratory
The Wen Laboratory studies epigenetic regulation of gene expression and chromatin dynamics. We are interested in understanding how dysregulation of the homeostasis of chromatin states leads to the development of human cancers, especially pediatric cancers, in an effort to develop small molecules for epigenetic therapies.

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Featured Publications

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Wan L# … Wen H#, Allis CD#. 2020. Impaired cell fate through gain-of-function mutations in a chromatin readerNature.

Wan L*, Wen H*, Li Y* et al. 2017. ENL links histone acetylation to oncogenic gene expression in AMLNature.
*Equal contribution

Li Y*, Wen H* et al. 2014. AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylationCell.
*Equal contribution

Wen H*, #, Li Y*, Xi Y*…Li W#, Li H#, Shi X#. 2014. ZMYND11 links histone H3.3 K36 trimethylation to transcription elongation and tumor suppressionNature.
*Equal contribution

Lab Announcements

Postdoctoral fellow position available
A postdoctoral fellow position is available immediately in the Wen Lab, which is focused on the study of epigenetic regulation of chromatin and transcription in cancer development. The long-term goal of the lab is to understand the molecular mechanisms by which histone modifications regulate chromatin and transcription, and how dysregulation of histone modification homeostasis leads to human cancers. Read the full posting here.

Wen Lab publishes new paper in Nature
The Wen Lab’s latest paper, Impaired cell fate through gain-of-function mutations in a chromatin reader, has been published in Nature! Read it here.